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| A Review of Organophosphorus Pesticide Biosensors Based on Acetylcholinesterase Inhibition |
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| DOI： |
| KeyWord:organophosphorus pesticides（OPs） acetylcholinesterase（AChE） biosensors enzyme inhibition |
| Author | Institution |
| PENG Zou-jun，QIU Ping |
Department of Chemistry，Nanchang University，Nanchang ，China |
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| Abstract: |
| Organophosphorus pesticides（OPs） residues have posed a great threat to natural ecosystem and human health by enrichment through the food chain．Traditional analytical methods for OPs detection，including high performance liquid chromatography（HPLC） and gas chromatography（GC） have some inevitable limitations，such as long response times，high cost，and requirements for complicated detection procedure and highly qualified operators. In recent years，biosensors have been effectively used in the field of quantitative analysis chemistry due to their strong specificity，high speed and high accuracy．The biosensors using acetylcholinesterase（AChE） as an identification element and catalytic element have opened up a bright prospect for the rapid and practical determination of OPs residues in real samples．In this review，the latest sensing strategies and devices based on AChE inhibition with different reaction mechanisms are summarized，especially the sensing devices combined with new generation detection technologies. The challenges and deficiencies for the current detection of OPs based on AChE inhibition are also summarized，and the future research direction is prospected. |
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