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| Strategy for Cascade Self-assembly/Disassembly of Small Molecules in Cancer Diagnosis and Treatment |
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| DOI： |
| KeyWord:in situ self-assembly ?cascade self-assembly/disassembly ?accurate delivery ?cancer diagnosis and treatment |
| Author | Institution |
| JIA De-ying，LI Shuang-shuang，ZHENG Zhen |
School of Pharmacy， Tianjin Medical University，Tianjin ，China |
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| Abstract: |
| Specific targeting of cancer cells is the key to accurate diagnosis and efficient treatment．Among current delivery strategies，small molecule-based precursor probes（or drugs） are limited by their rapid body metabolism and toxicity on healthy organs，while the efficacies of nanoprobes（or nano drug carrier） are hampered by their unclear molecular weight，low biological penetration and easy capture by the reticuloendothelial system. The strategy of "in situ self-assembly" combines the advantages of both small molecules and nano-systems．The use of small molecule as precursor could improve the biological penetration of drugs in tumor tissues，while the nanostructures formed by self-assembly after reaching the target site may provide better bioavailability，higher metabolic stability and longer residence time．On this basis，a cascade self-assembly/disassembly strategy for accurate localization in tumor and high selectivity towards tumor cells was further developed by applying multiple tumor－specific biomolecules to sequentially activate molecular precursors．In the diagnosis and treatment of cancer，this strategy could effectively improve the sensitivity of diagnostic signals，track a series of dynamic biological processes in cancer cells，and achieve effective drug accumulation in tumor cells while reduce side effects on normal cells．In this paper，the current progress of enhanced cascade self-assembly and disassembly of small molecules are summarized，which provides new insights for cancer diagnosis and treatment. |
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