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| In situ Autogenous Magnetic Resonance Imaging and Thermal Imaging of Cancer Using Hydrogen Peroxide Activated Nanoparticles |
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| DOI： |
| KeyWord:H2O2-activatable ?in situ autogenous MRI ?thermal imaging ?NIR－Ⅱregion ?cancer diagnosis |
| Author | Institution |
| WANG Shu-qi，AN Shang-jie，ZHEN Wen-yao，JIA Xiao-dan，WANG Yue，JIANG Xiu-e |
1. State Key Laboratory of Electroanalytical Chemistry，Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun ，China;2. University of Science and Technology of China，Hefei ，China |
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| Abstract: |
| Early accurate detection of malignancy tumor plays a key role in reducing cancer mortality．Current detection strategies mainly rely on the imaging technologies．However，single-modality biomedical image cannot provide enough information due to its inherent defects．Therefore，the dual-modal biomedical imaging strategies which can provide more available information for precise cancer diagnosing，have become a hotspot for research．Among the biomedical imaging methods applied in clinical，magnetic resonance imaging（MRI） is considered to be an effective method for clinicopathological diagnosis due to its high three-dimensional（3D） spatial resolution and high soft tissue resolution，but it has also been plagued by the long inspection time and expensive inspection fee．Whereas，thermal imaging is an efficient and minimally invasive method for biomedical imaging，which could offset the above deficiencies of MRI．Most importantly，it is convenient and economical．Furthermore，the development of multifunctional nanoparticles brings more possibilities for the establishment of novel tumor diagnostic platforms，which is expected to have a greater impact in the field of biomedical imaging．Thus，a kind of highly biocompatible multifunctional nanoparticles（CuSSe NPs） were prepared by a facile one-pot hydrothermal method for tumor MRI/thermal imaging in this study．The diameter of CuSSe NPs is about 100 nm，and it exhibited an excellent dispersity in aqueous solution．However，the CuSSe NPs did not exhibited the best MRI capability due to the existence of diamagnetic Cu（Ⅰ），but?in vivo?experiments demonstrated that the CuSSe NPs could specifically respond to the excess hydrogen peroxide（H2O2） at the tumor site so as to realize the conversion of diamagnetic Cu（Ⅰ） to paramagnetic Cu（Ⅱ），acting as in situ autogenous MRI agents for visualizing and diagnosing the location of cancer．Moreover，attributing to the intensive absorption in the second near-infrared（NIR－Ⅱ） region，CuSSe NPs exhibited as a concentration- and laser－power-dependent photothermal imaging agent with considerable photothermal conversion effects in the NIR－Ⅱ region．The photothermal conversion efficiency of CuSSe NPs was calculated to be－48% under the illumination of NIR－Ⅱ laser（1 064 nm）．Both?in vivo and in vivo experiments demonstrated that CuSSe NPs have good thermal imaging capabilities for real-time cancer monitoring．Furthermore，the blood analysis on the mice injected with or without CuSSe NPs were evaluated after 3 and 25 days．The results showed that CuSSe NPs were highly biocompatible without acute and long-term toxicity．Consequently，the constructed copper-based multifunctional NPs have been demonstrated to be a potential nanoprobe for dual-modal imaging with high tumor contrast in clinical cancer theranostics． |
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