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| Simultaneous Determination of 9 Novel Synthetic Indazoles Cannabinoids in“E－cigarette Oil”by Gas Chromatography－Mass Spectrometry |
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| DOI： |
| KeyWord:gas chromatography－mass spectrometry E－cigarette oil indazoles synthetic cannabinoid |
| Author | Institution |
| SONG Hui |
Department of Forensic Science and Technology，Criminal Investigation Police University of China， Shenyang ，China |
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| Abstract: |
| A gas chromatography－mass spectrometric（GC－MS） method was established for the analysis of novel synthetic indazoles cannabinoids in“E－cigarette oil”．The samples were extracted with methanol．With diazepam as internal standard，9 novel synthetic cannabinoids were then determined with an HP－5MS column（30 m × 0.25 mm × 0.25 μm） and quantified by internal standard method under such programmed temperature conditions，namely，setting the initial temperature at 200 ℃ for 1 min，then increasing the temperature to 260 ℃ at a rate of 20 ℃/min and keeping for 1 min，and finally increasing the temperature to 300 ℃ at a rate of 5 ℃/min and kept for 10 min．Meanwhile，the mass spectrum of the target fragment fracture manner was analyzed．9 target substances could be effectively separated in 20 min．And the correlation coefficients（r2） were all greater than 0.997 in the linear range of 1.0－100.0 μg/mL．The detection limits and quantitation limits were in the ranges of 0.04－0.25 μg/mL and 0.15－0.85 μg/mL， respectively．The recoveries ranged from 95.1% to 104%，with intra-day relative standard deviations（RSDs） and inter-day RSDs less than 4.6% and 8.4%，respectively．The results showed that the method is effective，accurate and sensitive，and it could be applied to the analysis for actual cases. |
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