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| Progress on In Situ Imaging of Heavy Metals in Living Organisms |
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| DOI： |
| KeyWord:heavy metals in-situ imaging technology laser ablation inductively coupled plasma mass spectrometry（LA－ICP－MS） synchrotron radiation metal sensing fluorophore |
| Author | Institution |
| PEI Cheng-cheng，NIE Ya-guang，ZHAO Ya-nan，NI Shen-yao，XU An |
1. Institute of Material Science and Information Technology，Anhui University，Hefei ，China; 2. Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology，High Magnetic Field Laboratory， Hefei Institutes of Physical Science，Chinese Academy of Sciences，Hefei ，China |
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| Abstract: |
| Heavy metals are ubiquitously present in the natural environment．Due to their high toxicity，different occurrences and resistance to microorganism decomposition，they are highly prone to accumulate and cause harm when they enter into living organisms through various pathways．The differences in the distribution and occurrence of heavy metals in organisms are the key factors that determine their biological effects，thus understanding these key factors is the basis for exploring their toxicological mechanisms．In-situ imaging technology has received widespread attention as it is designed to spatially identify heavy metals in organisms，which enables the visual evaluation of heavy metal content，distribution，transformation，as well as intake and excretion．The basic principles and applications of in-situ imaging methods for heavy metals are summarized in this paper，including laser ablation inductively coupled plasma mass spectrometry（LA－ICP－MS），synchrotron radiation and metal sensing fluorophore imaging，and their respective technical characteristics and application scenarios are compared．The perspectives on future development of in-situ imaging of heavy metals in living organisms are also provided． |
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