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| Progress in Raman Spectroscopy for Chiral Compounds Detection |
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| DOI： |
| KeyWord:Raman spectrum chiral compounds research progress |
| Author | Institution |
| LI Dan，HU Rui-qi，LI Gong-ke，XIA Ling |
School of Chemistry，Sun Yat-sen University，Guangzhou ，China |
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| Abstract: |
| The structures and physicochemical properties of chiral compounds are similar，but their pharmacological effects or toxicity levels in living species are quite different，and their improper usage might hurt humans greatly．As a result，developing an effective and precise approach for chiral compounds detection is critical．However，traditional detection methods are tedious，time-consuming，and difficult to identify chiral compounds in complex systems，which severely limit the progress of chiral chemistry．Raman spectroscopy，as a powerful surface-interface analysis technique，could not only provide rich structural information of compounds，but also have the advantages of nondestructive and rapid detection，showing a broad application prospect in the detection of chiral compounds．In this paper，recent development of Raman spectroscopy in the detection of chiral compounds is reviewed，including Raman photoactivity spectroscopy，enantioselective Raman spectroscopy，low frequency Raman spectroscopy，and surface-enhanced Raman scattering spectroscopy．Finally，the problems that need to be solved urgently are presented，and the development trend is foreseen. |
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