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| Determination of Migration of Six Cyclosiloxanes in Silicone Rubber Products for Food Contact by GC－MS/MS |
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| DOI： |
| KeyWord:food contact silicone rubber cyclosiloxane food simulant migration gas chromatography－tandem mass spectrometry（GC－MS/MS） |
| Author | Institution |
| GE Dan-yang，LIU Gui-hua，JIANG Huan，ZHU Yu-xiao，SHANG Gui-qin，LUO Shi-peng，HU Chang-ying |
1. Department of Food Science and Engineering，Jinan University，Guangzhou ，China; 2. Changzhou Industrial and Consumable Products Inspection Company Limited，Changzhou ，China; 3. Nanjing Customs Testing Center for Dangerous Goods and Packaging，Changzhou ，China; 4. School of Chemical and Environmental Engineering，Jiangsu University of Technology，Changzhou ，China |
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| Abstract: |
| A method for the determination of the migration of six cyclosiloxanes（D4－D9） to 50% ethanol，95% ethanol and isooctane in food contact silicone rubber products was developed based on gas chromatography－tandem mass spectrometry（GC－MS/MS），which was applied to the determination of 38 actual samples．2 mL of n-hexane was used to extract D4－D9 from 10 mL of 50% ethanol obtained from the migration test? followed by filtration and detection．Meanwhile，the 95% ethanol and isooctane were simply determined after filtration．The analysis was carried out in multiple reaction monitoring mode using an HP－5 MS column for separation．The results showed that there were good linear relationships for D4－D9 in the range of 0.05－1.00 mg/L or 0.20－5.00 mg/L，with correlation coefficients（r2） not less than 0.996 0．The limits of detection and limits of quantitation for each target were in the range of 0.02－0.07 mg/L and 0.05－0.20 mg/L，respectively．The recoveries ranged from 90.1% to 106%，with relative standard deviations not more than 13%．The method was used to determine the migration of D4－D9 in commercially available food contact silicone rubber products，and it was found that there was a migration risk of D4－D9 to 50% ethanol，while the migration risk of D4－D9 to 95% ethanol and isooctane was the highest as the detection rate for D4－D9 was 80%．The detection rate for the third migration of D4－D9 to 95% ethanol and isooctane was significantly greater than that for the first migration，while the detection rates for the first migration and the third migration to 50% ethanol were not significantly different. |
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