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| Simultaneous Determination of 23 Organic Antibacterial Agents in Food Contact Paper Products by UPLC－Orbitrap HRMS |
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| DOI： |
| KeyWord:food contact paper products organic antibacterial agent chlorophenols parabens ultra-high performance liquid chromatography－orbitrap high resolution mass spectrometry（UPLC－Orbitrap HRMS） |
| Author | Institution |
| LIU Yi-feng，QIU Jia-xing，ZHANG Peng-jie，SUN Ke-qiang，ZHANG Xian-chen，ZHAO Zhen-yu，LIANG Run-mei |
Zhongshan Customs Technology Center，Zhongshan ，China |
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| Abstract: |
| An ultra-high performance liquid chromatography－orbitrap high resolution mass spectrometric（UPLC－Orbitrap HRMS） method was established for the determination of 23 organic antibacterial agents，including 4 parabens and 19 chlorophenols in food contact paper products．The samples were ultrasonically extracted with methanol as extraction solvent，then centrifuged，concentrated and fixed volume by nitrogen blowing，filtered by 0.22 μm membrane，and finally analyzed by UPLC－Orbitrap HRMS．The separation was performed on a Waters Atlantis T3 （150 mm × 2.1 mm，3 μm） by gradient elution，using methanol－5 mmol/L ammonium acetate containing 0.4% acetic acid as mobile phase．Electrospray ionization（ESI-） mode was used for ionization，and full MS/dd－MS2 scanning mode for MS．Retention time and secondary subion MS spectrum were used for qualitative analysis，and chromatography peak area of extracted ions was quantified．The limits of quantitation for parabens and chlorophenols were 0.05 μg/kg and 0.05 mg/kg，respectively，and the linear relationships were good in the ranges of 0.05－5.0 ng/mL and 0.05－5.0 μg/mL，respectively，with correlation coefficients greater than 0.997．The average recoveries for blank matrix samples at three spiked concentrations ranged from 81.7% to 119%，with relative standard deviations of 2.0%－8.8%．The method is convenient and efficient，and could be used for screening and confirmation of organic antibacterial agents in food contact paper. |
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