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| Research Progress on Untargeted Screening of Compounds in Food Contact Materials |
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| DOI： |
| KeyWord:food contact materials untargeted screening qualitative analysis data processing high resolution mass spectrometry |
| Author | Institution |
| SU Qi-zhi，DONG Ben，LI Dan，ZHONG Huai-ning |
National Reference Laboratory for Food Contact Material（Guangdong），Guangzhou Customs District Technology Center，Guangzhou ，China |
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| Abstract: |
| As a potential risk to food safety，chemical migration from food contact materials（FCM） is attracting growing interest in the last decades，which promotes the development of analytical techniques. Conventional target analyses mainly focus on some intentionally added substances（IAS） and few non-intentionally added substances（NIAS），which are therefore incapable of screening other potentially present substances. In contrast，untargeted screening analysis covers all detectable substances，providing chemical information derived from FCM as comprehensive as possible，which is fundamental for the risk assessment，legislation，and risk management of FCM. However，challenges remain in untargeted screening analysis of FCM nowadays. This work provides an overview on untargeted screening technology used in FCM with a focus on chemical extraction and identification on FCM. The potential of mass spectrum libraries is highlighted，especially publically available libraries，high resolution mass spectrometry，open-source tools，chemical databases pertinent to FCM，as well as retention index and collision cross section（CCS） predictions，etc.，in the qualification of substances derived from FCM. The work is also helpful to ultilize various resources and tools to facilitate untargeted screening analysis in the field of FCM. |
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