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| Determination of 53 Pesticide Residues in Phytocosmetics by Gas Chromatography－Tandem Mass Spectrometry |
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| DOI： |
| KeyWord:gas chromatography－tandem mass spectrometry（GC－MS/MS） solid phase extraction phytocosmetics pesticide residues |
| Author | Institution |
| LIANG Zi-yang，LIANG Zi-hao，MA Ye-fen，LUO Hui-tai，HUANG Fang，WU Hui-qin |
Guangdong Provincial Engineering Research Center for Quality and Safety of Traditional Chinese Medicine，Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology， Institute of Analysis，Guangdong Academy of Sciences（China National Analytical Center， Guangzhou），Guangzhou ，China |
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| Abstract: |
| A gas chromatography－tandem mass spectrometry（GC－MS/MS） with solid phase extraction（SPE） was developed for the determination of 53 pesticides residues in phytocosmetics．The phytocosmetics samples were firstly extracted with acetonitrile，then the lipid substances in acetonitrile extract were removed by centrifugation under freezing condition．Concentration and clean-up steps were performed by solid phase extraction．After the pretreatment，the samples were separated on an Agilent VF－17ms capillary column（30 m × 0.25 mm × 0.25 μm），then detected by GC－MS/MS in selective reaction monitoring（SRM） mode and quantified by matrix-matched calibration．Results showed that there were good linear relationships for the 53 analytes with their correlation coefficients（r2） of 0.996 1－0.999 9．The limits of detection（LODs） and the limits of quantitation（LOQs） were in the range of 0.01－0.02 mg/kg and 0.02－0.05 mg/kg，respectively．The average recoveries for 53 pesticides in the samples ranged from 77.1% to 105%，with the relative standard deviations（RSDs，n = 6） of 0.50%－4.9%．The method was applied to the determination of 30 phytocosmetics samples，of which two positive samples were found．This method is simple，convenient，accurate and sensitive，which is suitable for the determination of 53 pesticide residues in phytocosmetics and could provide technical support for ensuring the quality and safety of cosmetics. |
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