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| Portable Detection of Ca2+ Using Writing Robots Drawing Paper-based Microfluidic Chips |
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| DOI： |
| KeyWord:paper-based microfluidic chip writing robot hydrogel rapid detection visual quantitative detection |
| Author | Institution |
| LIU Xu，GAO Guo-wei，HU Jing-fang，ZHANG Kai-yu，LI Yan-sheng |
1. Key Laboratory of Sensors，Beijing Information Science and Technology University，Beijing ，China;
2. MOE Key Laboratory of Modern Measurement and Control Technology，Beijing Information Science and Technology University，Beijing ，China;
3. Joint State Key Laboratory of Sensing Technology，Shanghai Institute of Microsystems and Information Technology， Chinese Academy of Sciences，Shanghai ，China |
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| Abstract: |
| The paper-based microfluidic chips are a kind of paper-based chips，which have the advantages of excellent performance，low price，safety and portability．However，the preparation technology for paper-based microfluidic chips mostly depends on the professional and expensive equipments，which limits their development to a certain extent．And it is not conducive to the commercialization process for paper-based microfluidic chips．In this paper，a paper-based microfluidic chip with hydrogel valve was developed by using a low-cost，simple home writing robot to draw a smart hydrogel with sensitive properties on a paper base．In order to verify the feasibility of the preparation method，Ca2+ was used as a model target．Results showed that the paper-based microfluidic chip prepared by this method could achieve the quantitative detection of Ca2+ solutions in the concentration range of 0.1－50 mmol/L with the naked eye，which has good usability and reproducibility．Meanwhile，a ILX506 CCD sensor was used to design and optimize the digital display device of the paper-based microfluidic chip so as to realize the automatic reading function for the measurement results of paper-based microfluidic chip．The experimental results showed that this method could be used for the rapid and convenient preparation of multiple paper-based microfluidic chips at low cost．The preparation method provides a new research idea for the ubiquitous preparation of paper-based microfluidic chips，which has a good promotion prospect in those developing regions. |
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