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| Simultaneous Determination of 10 New Synthetic Cannabinoids in Blood by UPLC－QE－Orbitrap MS with QuEChERS Extraction |
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| DOI： |
| KeyWord:QuEChERS UPLC－QE－Orbitrap MS blood new synthetic cannabinoid |
| Author | Institution |
| ZHANG Zhi-yuan，SONG Hui，LI Xiang，XU Ying-jian，ZHU Yu，WANG Lei |
1. Department of Forensic Science and Technology，Criminal Investigation Police University of China， Shenyang ，China;
2. Kashgar Public Security Bureau，Kashgar ，China |
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| Abstract: |
| An ultra liquid chromatography－quadrupole/electrostatic field orbitrap mass spectrometry（UPLC－QE－Orbitrap MS） with QuEChERS extraction was developed for the simultaneous determination of 10 new synthetic cannabinoids in blood．The whole blood samples were firstly extracted by optimized QuEChERS method，then separated on an Hypersil GOLDTM Vanquish column（100 mm × 2.1 mm，1.9 μm） by gradient elution，with 0.1% formic acid water and 0.1% formic acid acetonitrile as mobile phases，and finally determined with positive heated electrospray ion source（HESI+） in parallel reaction monitoring（PRM） mode．The results indicated that the calibration curves for 10 target compounds exhibited good linear relationships in their respective mass concentration ranges，with correlation coefficients（r2） not less than 0.999 0．The limits of detection（LODs） and limits of quantitation（LOQs） for 10 compounds were in the range of 0.01－0.05 ng/mL and 0.05－0.20 ng/mL，respectively．The recoveries for 10 compounds ranged from 92.1% to 115%，and the matrix effects ranged from 86.6% to 115%，with the intra-day relative standard deviations（RSDs） and the inter-day RSDs not more than 8.5% and 10%，respectively．The method has the advantages of simple operation，good selectivity，high sensitivity and recovery，and it is suitable for the identification of synthetic cannabinoids in whole blood samples. |
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