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| Application of Aptamer Biosensor in Detection of Aflatoxin B1 |
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| DOI： |
| KeyWord:aflatoxin B1 aptamer biosensor application |
| Author | Institution |
| HAN Wen-hao，LI Yan-sheng，GAO Guo-wei，ZHANG Xue-ji |
1. Key Laboratory of Sensors，Beijing Information Science and Technology University，Beijing ，China; 2. Key Laboratory of Modern Measurement and Control Technology of Ministry of Education，Beijing Information Science and Technology University，Beijing ，China; 3. School of Biomedical Engineering， Shenzhen University，Shenzhen ，China |
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| Abstract: |
| Aflatoxin B1（AFB1） has strong toxicity and carcinogenicity，and its dose exceeding the standard will seriously endanger the health of organisms．The development of new AFB1 detection methods is of great significance for the prevention and control of its harm．The traditional method for AFB1 detection is mature and reliable，with low detection limit，but relying on professional equipment and professionals．It cannot meet the needs of on-site detection．Aptamer biosensors have the advantages of high sensitivity，high specificity and simple operation，which have attracted attention in the detection of AFB1．Meanwhile，researchers have developed many new methods based on different principles．The related properties of AFB1 and its traditional detection methods are firstly introduced in this paper，and then the construction of aptamer biosensors based on optical，electrochemical and microfluidic chips in recent years as well as their applications in the field of AFB1 detection are summarized．It provides a reference for the development of practical application of aptamer biosensors，and discusses the development prospects and future trends of aptamer biosensors by discussing the problems in the currently developed detection methods. |
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